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It reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT)
Product Name Pomalidomide-CO-C6-Br Synonyms Pomalidomide-4'-CO-C6-Br CAS Number n/a Related CAS Molecular Formula C20H22BrN3O5 Molecular Weight 464
Binfunctional amine-amine linker
Single isomer 6-FAM ethylenediamine
Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP coumarin It reduces mHTT levels throughSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload
