Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan macrophage Product Name Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS

Product Name Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C55H85N7O20 Molecular Weight 1164

Product Name Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Synonyms CAS Number Related CAS Molecular Formula C45H59N11O14 Molecular Weight 978

041 Purity (HPLC) >= 95% Solubility DMSO

89 SMILES ClCCOCCOCCOCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan macrophage Product Name Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CASSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU